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Kidney problems can sometimes occur with the use of NSAID medicationsincluding ketorolacProblems are more likely to occur if you are dehydratedhave heart failure or kidney diseaseare an older adultor if you take certain medicationssee also Drug Interactions sectionDrink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

A blood thinner such as warfarinCoumadinlithiumEskalithLithobidmethotrexateRheumatrexTrexallthiothixeneNavanealprazolamXanaxdiureticswater pillssuch as furosemideLasixmuscle relaxerssteroidsprednisone and othersseizure medications such as carbamazepineCarbatrolTegretolor phenytoinDilantina heart or blood pressure medication such as candesartanAtacandeprosartanTevetenirbesartanAvaproAvalidelosartanCozaarHyzaarvalsartanDiovantelmisartanMicardisor olmesartanBenicaror aspirin or other NSAIDs such as etodolacLodineflurbiprofenAnsaidindomethacinIndocinketoprofenOrudisketorolacToradolmefenamic acidPonstelmeloxicamMobicnabumetoneRelafennaproxenAleveNaprosynpiroxicamFeldeneand othersor an ACE inhibitor such as benazeprilLotensincaptoprilCapotenfosinoprilMonoprilenalaprilVasoteclisinoprilPrinivilZestrilramiprilAltaceand others.

Older adults may be more sensitive to the effects of the drugespecially bleeding in the stomach/intestines or kidney problemsUsing high doses for a long time may increase this risk.

This medication is given by injection into a muscle or vein as directed by your doctorIt may be given as a one-time dose or given on a regular scheduleIf given on a regular scheduleit is usually injected every 6 hours as neededor as directed by your doctorThis drug must not be injected into the spine.

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