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It is commndd that liv nzym tsts b obtaind pitinitiating thapy with ATOLIP CV and patd as clinically indicatd. Th hav bn a postmakting pots atal and non-atal hpatic ailu in patints taking statins, including atovastatin. I sious liv injuy with clinical symptoms and/hypbiliubinmia jaundic occus duing tatmnt with ATOLIP CV , pomptly intupt thapy. I an altnat tiology is not ound, dnot stat ATOLIP CV.

Poton Pump Inhibitos : Avoid concomitant us ATOLIP CV with ompazol sompazol. In clinical studis, ompazol was shown tduc th antiplatlt activity clopidogl whn givn concomitantly 12 hous apat. A high dos gimn clopidogl concomitantly administd with ompazol incass antiplatlt spons; an appopiat dos gimn has not bn stablishd. A simila duction in antiplatlt activity was obsvd with sompazol whn givn concomitantly with clopidogl. Consid using anoth acid-ducing agnt with minimal nCYP2C19 inhibitoy ct on th omation clopidogl activ mtabolit. Dxlansopazol, lansopazol and pantopazol had lss ct on th antiplatlt activity clopidogl than did ompazol sompazol.

Avoid using ompazol sompazol with ATOLIP CV . Ompazol and sompazol signiicantly duc th antiplatlt activity clopidogl. Whn concomitant administation a PPI is quid, consid using anoth acid-ducing agnt with minimal nCYP2C19 inhibitoy ct on th omation clopidogl activ mtabolit.

Thapy with lipid-alting agnts should b only on componnt multipl isk actintvntion in individuals at signiicantly incasd isk athosclotic vascula disas du thypcholstolmia. Dug thapy is commndd as an adjunct tdit whn th spons ta dit stictd in satuatd at and cholstol and oth nonphamacologic masus alon has bn inadquat. In patints with CHD multipl isk actos CHD, atovastatin can b statd simultanously with dit.

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