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The following reactions have been identified during postmarketing use of XALATAN in clinical practiceBecause they are reported voluntarily from a population of unknown sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposureThe reactionswhich have been chosen for inclusion due to either their seriousnessfrequency of reportingpossible causal connection to XALATANor a combination of these factorsinclude:
Reduction of elevated intraocular pressure in paediatric patients with elevated intraocular pressure and paediatric glaucoma.
Apply this medication in the affected eye(susually once daily in the eveningor as directed by your doctorDo not use this medication more frequently than prescribedusing more can decrease effectiveness.
Latanoprost was not mutagenic in bacteriain mouse lymphomaor in mouse micronucleus testsChromosome aberrations were observed in vitro with human lymphocytesAdditional in vitro and in vivo studies on unscheduled DNA synthesis in rats were negative.
Latanoprost is absorbed through the cornea where the isopropyl ester prodrug is hydrolyzed to the acid form to become biologically active.
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