Crewe are High of Sky Bet League Two Following a 4-2 win at Carlisle on Saturday.
Alexandra took an early lead thanks to goals from Nicky Hunt and Daniel Powell in first half, but were pegged back by strikes against Christie Elliot and Hallam Hope.
Crewe ensured the win thanks to Chris Porter plus a Gethin Jones aim, and then broke back, however.
They lead after the Grecians beat previous leaders Forest Green 1-0 at St James Park Exeter on goals taken. Ryan Bowman has got the only goal as Rovers fell to fourth.
Bradford moved up to third after a 2-1 win at Morecambe – that dropped into the bottom of the table after Stevenage made their first win of the year.
Swindon, meanwhile, stay seventh after a 1-1 draw. Eoin Doyle put the Robins but a stage was got by Joel Grant for Argyle.
Nicky Maynard scored a hat-trick at the 1 Call Arena since Mansfield beat nine-man Oldham 6-1. Oldham had two players sent off since Tomas Egert over a moment in the first half and Felipe Morais were dismissed.
While Leyton Orient came from behind Walsall to win 3-1 since they thumped Northampton 3-0 scunthorpe earned a triumph of the year.
Elsewhere, Macclesfield beat Port Vale 2-1, Crawley overcome Colchester by exactly the same scoreline and Salford watched Cambridge 1-0.
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