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Dipyridamole inhibits phosphodiesterasePDEin various tissuesWhile the inhibition of cAMP-PDE is weaktherapeutic levels of dipyridamole inhibit cyclic-35guanosine monophosphate-PDEcGMP-PDEthereby augmenting the increase in cGMP produced by EDRFendothelium-derived relaxing factornow identified as nitric oxide

Hepatic InsufficiencyElevations of hepatic enzymes and hepatic failure have been reported in association with dipyridamole administration.

It is believed that platelet reactivity and interaction with prosthetic cardiac valve surfacesresulting in abnormally shortened platelet survival timeis a significant factor in thromboembolic complications occurring in connection with prosthetic heart valve replacement.

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