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For patients with intravascular volume-depletione.gthose treated with high-dose diureticsa starting dose of 25 mg once daily should be consideredsee section 4.4

Kidney problemslittle or no urinationpainful or difficult urinationswelling in your feet or anklesfeeling tired or short of breath.

Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patientsa lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience with losartan in patients with severe hepatic impairmentTherefore losartan must not be administered in patients with severe hepatic impairmentsee sections 4.24.3 and 5.2

See ContraindicationsHyperkalemia with KsupplementsKsparing diureticsKcontaining salt substitutesMay be antagonized byand renal toxicity potentiated by NSAIDsincluding selective COX-2 inhibitorsmonitor renal function periodically in elderly and/or volume-depletedMonitor lithiumDual inhibition of the renin-angiotensin system with ARBsACEIsor aliskiren may increase risk of hypotensionhyperkalemiarenal function changesmonitor closelyAvoid concomitant aliskiren in renal impairmentCrClsupplementsKsparing diureticsKcontaining salt substitutesMay be antagonized byand renal toxicity potentiated by NSAIDsincluding selective COX-2 inhibitorsmonitor renal function periodically in elderly and/or volume-depletedMonitor lithiumDual inhibition of the renin-angiotensin system with ARBsACEIsor aliskiren may increase risk of hypotensionhyperkalemiarenal function changesmonitor closelyAvoid concomitant aliskiren in renal impairmentCrCl.

Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use Cozaar only for the indication prescribed.

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