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Celecoxib has been associated with anaphylactic reactions in patients with and without known hypersensitivity to celecoxib and in patients with aspirin sensitive asthmaCelebrex is a sulfonamide and both NSAIDs and sulfonamides may cause allergic type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible peoplesee CONTRAINDICATIONS and Exacerbation Of Asthma Related To Aspirin Sensitivity

An increase in the incidence of background findings of spermatocele with or without secondary changes such as epididymal hypospermia as well as minimal to slight dilation of the seminiferous tubules was seen in the juvenile ratThese reproductive findings while apparently treatment-related did not increase in incidence or severity with dose and may indicate an exacerbation of a spontaneous conditionSimilar reproductive findings were not observed in studies of juvenile or adult dogs or in adult rats treated with celecoxibThe clinical significance of this observation is unknown.

He says ulcerative colitis patients often have significant pain from arthritis or joint pain and frequently use anti-inflammatory drugs to treat the painHowevertraditional anti-inflammatory drugslike ibuprofen and naproxenhave been linked to ulcerative colitis flare-upsThis study suggests that Celebrex is a good alternative to other anti-inflammatory drugs.

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Do not use this medicine just before or after heart bypass surgerycoronary artery bypass graftor CABG

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