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Fatal overdosesboth accidental and intentionalhave been reported in adults and children who have ingested colchicineSee OVERDOSEColchicine capsules should be kept out of the reach of children.

The magnitude of interactions with strong and moderate CYP3A4 inhibitors as well as with P-gp inhibitors from performed in vivo studies is summarised in the table below:

Advise the patient that fatal overdosesboth accidental and intentionalhave been reported in adults and children who have ingested colchicineColchicine capsules should be kept out of the reach of children.

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their studies suggest decreasing by about half the amount of colchicine used in acute attacks of gout as well as in renal failure patients.

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