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The sympatholytic action of clonidine may worsen sinus node dysfunction and atrioventricularAVblockespecially in patients taking other sympatholytic drugsThere are post-marketing reports of patients with conduction abnormalities and/or taking other sympatholytic drugs who developed severe bradycardia requiring IV atropineIV isoproterenol and temporary cardiac pacing while taking clonidine.
Clonidine acutely stimulates growth hormone release in both children and adultsbut does not produce a chronic elevation of growth hormone with long-term use.
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