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ARALEN is indicated for the suppressive treatment and for acute attacks of malaria due to PvivaxP.malariaePovaleand susceptible strains of PfalciparumThe drug is also indicated for the treatment of extraintestinal amebiasis.
Chloroquine is well tolerated by most peopleeven for long-term therapyThe side effects include mild gastrointestinal tract complaintswhich are usually alleviated if the drug is taken with mealsoccasional headachesblurred visiondizzinessfatigueconfusiondepigmentation of hairskin eruptionscorneal opacityweight lossand myalgiasIntense pruritusa common complaint among black Africans taking the drugusually is relieved with antihistaminesChloroquine is contraindicated in patients with psoriasisretinal diseaseor porphyria.
Chloroquine causes a toxic myopathy but also produces a toxic neuropathyChloroquine is an antimalarial drug also used for the treatment of severe rheumatoid arthritissystemic lupus erythematosusand other dermatological diseasesThe clinical features of chloroquineinduced neuropathy are those of symmetrical sensorimotor polyneuropathyBoth axonal damage and primary demyelination have been reportedA prominent pathological feature of chloroquine neuropathy is ultrastructural intracytoplasmatic lamellar inclusionsresembling those described in amiodarone neuropathywithin Schwann cells and in perineurial and endothelial cells but not in axonsOnly long-term treatment has been associated with chloroquine neuropathyfollowed by complete recovery after drug withdrawal.
Children are especially sensitive to an overdoseso keep the medication out of the reach of children.
Chloroquine is active against the erythrocytic forms of Plasmodium vivaxPlasmodium malariaeand susceptible strains of Plasmodium falciparumbut not the gametocytes of PfalciparumIt is not effective against exoerythrocytic forms of the parasite.
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two competing models explaining chloroquine resistance in plasmodium falciparum.
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